A display of assorted desserts including chocolate-covered pastries, fruit tarts, and cheesecakes.
Photo by Majid Shaheen
Open Photo by Majid Shaheen

Central San Mateo Vacations from $155

Book a Hotel + Flight or Car together to unlock savings

Your Central San Mateo Vacation

Book a Central San Mateo vacation package and discover the way of life and vibe of this unique neighborhood. With all your travel plans taken care of, the only thing you need to concentrate on here is having an absolute ball. Some top nearby attractions to visit during your trip to Central San Mateo include Coyote Point Park, Hillsdale Shopping Center and Poplar Creek Golf Course. Expedia can help turn your ideal Central San Mateo vacation into reality, whatever your budget or travel plans.

The Latest Central San Mateo Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
    Dec 28 - Dec 30

    Aqua Breeze Inn + Flight

    Westside Santa Cruz
    2 nights
    2.5 star property
    8.2/10 - Very good (1,004 reviews)
    Roundtrip • Los Angeles (LAX) - San Jose (SJC)
    LAX - SJC • Nonstop SJC - LAX • Nonstop
    $260
    $155
    per traveler
    found 1 day ago
    Aqua Breeze Inn
  • A hotel room with two beds, a desk, a chair, a large window, and a bathroom with a sink and mirror.
    Jan 23 - Jan 25

    The Grove Inn + Flight

    Western Addition
    2 nights
    3.0 star property
    9.2/10 - Wonderful (751 reviews)
    Roundtrip • Los Angeles (LAX) - San Francisco (SFO)
    LAX - SFO • Nonstop SFO - LAX • Nonstop
    $333
    $192
    per traveler
    found 1 day ago
    The Grove Inn
  • A modern house with a large glass facade, outdoor seating area, and a swimming pool.
    Jan 17 - Jan 22

    Cavallo Point + Flight

    Sausalito
    5 nights
    4.5 star property
    9.2/10 - Wonderful (1,001 reviews)
    "Front desk staff, restaurant (hostess and servers) and Brit were amazing at understanding our needs and requests. We were staying at Cavello after a major surgery and they each made my stay comfortable and welcoming. Fabulous meals, drinks and room amenities."
    Reviewed November 4, 2026
    Roundtrip • San Diego (SAN) - San Francisco (SFO)
    SAN - SFO • Nonstop SFO - SAN • Nonstop
    $1,783
    $1,077
    per traveler
    found 1 day ago
    Cavallo Point
  • A cityscape at dusk with illuminated buildings and a clear view of the skyline.
    Jan 7 - Jan 10

    Stanford Court San Francisco + Flight

    Downtown San Francisco
    3 nights
    4.0 star property
    9.0/10 - Wonderful (1,843 reviews)
    Roundtrip • Burbank (BUR) - San Francisco (SFO)
    BUR - SFO • Nonstop SFO - BUR • Nonstop
    $702
    $430
    per traveler
    found 1 day ago
    Stanford Court San Francisco
  • A modern bedroom with a large bed, a wall mural, a hanging light fixture, and a window with curtains.
    Jan 9 - Jan 13

    Marbella Lane - 3BR Designer Near Valley Fair + Flight

    San Jose
    4 nights
    3.0 star property
    Roundtrip • Dallas (DFW) - San Jose (SJC)
    DFW - SJC • Nonstop SJC - DAL • 1 stop
    Save 100% on your flight
    $1,629
    $1,059
    per traveler
    found 23 hours ago
    Marbella Lane - 3BR Designer Near Valley Fair

Where to stay in Central San Mateo

Find the best Central San Mateo areas and neighborhoods for the activities you enjoy most.
A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

A pier with a large number of sea lions resting on floating platforms.

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

A city street with tall buildings, flags, and cars.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

A cityscape with a prominent skyscraper, a bridge, and a mix of modern and historic buildings.

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

Discover the most popular places to visit in Central San Mateo

Central Park

8.6/10 (125 reviews)
Central Park is just one of the places to see in San Mateo, so why not enjoy the other things to explore during your travels? Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
See properties

What to do near Central San Mateo

From San Francisco: Highway 1 Self-Drive Audio Tour

Pacific Coast Highway App-Based Driving Audio Tour

$20
per traveler
90% of travelers recommend
Pacific Coast Highway App-Based Driving Audio Tour
See all activities near Central San Mateo

Central San Mateo Hotel Deals

A modern kitchen with white cabinetry, a stainless steel refrigerator, and a microwave.

@ Marbella Lane - Bright and Cozy Home Near SFO

@ Marbella Lane - Bright and Cozy Home Near SFO
3.0 star property
Central San Mateo
$289 nightly
The price is $325
Dec 2 - Dec 3
Total with taxes and fees
@ Marbella Lane - Bright and Cozy Home Near SFO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Central San Mateo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.